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Inactivation block of the HERG human cardiac K(+) channels by RP58866

1. RP58866 possesses a unique electrophysiological property: highly effective against various types of arrhythmias including ventricular fibrillation in animal models, noticeably those occurring during ischaemia with depolarized membrane due to elevated extracellular K(+) concentrations. To understa...

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Autores principales: Wang, Huizhen, Shi, Hong, Wang, Zhiguo
Formato: Artigo
Lenguaje:Inglês
Publicado: 1999
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1566185/
https://ncbi.nlm.nih.gov/pubmed/10482922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702741
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