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Bronchodilator and anti-inflammatory activities of glaucine: In vitro studies in human airway smooth muscle and polymorphonuclear leukocytes

1. Selective phosphodiesterase 4 (PDE4) inhibitors are of potential interest in the treatment of asthma. We examined the effects of the alkaloid S-(+)-glaucine, a PDE4 inhibitor, on human isolated bronchus and granulocyte function. 2. Glaucine selectively inhibited PDE4 from human bronchus and polym...

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Detalhes bibliográficos
Main Authors: Cortijo, J, Villagrasa, V, Pons, R, Berto, L, Martí-Cabrera, M, Martinez-Losa, M, Domenech, T, Beleta, J, Morcillo, E J
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1566148/
https://ncbi.nlm.nih.gov/pubmed/10455321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702702
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