E5531, a synthetic non-toxic lipid A derivative blocks the immunobiological activities of lipopolysaccharide

1. The major pathological responses to Gram-negative bacterial sepsis are triggered by endotoxin or lipopolysaccharide. As endotoxin is shed from the bacterial outer membrane, it induces immunological responses that lead to release of a variety of cytokines and other cellular mediators. As part of a...

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Main Authors: Kawata, Tsutomu, Bristol, John R, Rossignol, Daniel P, Rose, Jeffrey R, Kobayashi, Seiichi, Yokohama, Hiromitsu, Ishibashi, Akira, Christ, William J, Katayama, Koichi, Yamatsu, Isao, Kishi, Yoshito
Format: Artigo
Jezik:Inglês
Izdano: 1999
Teme:
Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1566082/
https://ncbi.nlm.nih.gov/pubmed/10433491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702596
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