Differential pharmacology between the guinea-pig and the gorilla 5-HT(1D) receptor as probed with isochromans (5-HT(1D)-selective ligands)

1. Both the 5-HT(1D) and 5-HT(1B) receptors are implicated in migraine pathophysiology. Recently isochromans have been discovered to bind primate 5-HT(1D) receptors with much higher affinity than 5-HT(1B) receptors. In the guinea-pig, a primary animal model for anti-migraine drug testing, however, i...

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Detalhes bibliográficos
Main Authors: Pregenzer, Jeffrey F, Alberts, Glen L, Im, Wha Bin, Slightom, Jerry L, Ennis, Michael D, Hoffman, Robert L, Ghazal, Nabil B, TenBrink, Ruth E
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1566017/
https://ncbi.nlm.nih.gov/pubmed/10385247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702532
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