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Pharmacological analysis of the novel, selective α(1)-adrenoceptor antagonist, KMD-3213, and its suitability as a tritiated radioligand
1. Pharmacological profiles of tritiated KMD-3213, a new antagonist of α(1)-adrenoceptor (AR), were examined in recombinant and native α(1)-AR, and compared with those of prazosin (PZ) and tamsulosin (YM-617). 2. In saturation experiments, [(3)H]-KMD (10–2000 pM) showed high affinity for α(1a)-AR (p...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1565976/ https://ncbi.nlm.nih.gov/pubmed/10369451 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702489 |
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