A comparison of the inhibitory activity of PDE4 inhibitors on leukocyte PDE4 activity in vitro and eosinophil trafficking in vivo

1. Phosphodiesterase (PDE) 4 inhibitors have been shown to inhibit eosinophil PDE4 activity in vitro and accumulation of eosinophils in experimental airways inflammation. However, direct effects on eosinophil trafficking have not been studied in detail and it is not known if activity in vitro transl...

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Autores principales: Cooper, Nicola, Teixeira, Mauro M, Warneck, Julie, Miotla, Jadwiga M, Wills, Ruth E, Macari, David M T, Gristwood, Robert W, Hellewell, Paul G
Formato: Artigo
Lenguaje:Inglês
Publicado: 1999
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Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565970/
https://ncbi.nlm.nih.gov/pubmed/10372831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702520
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