Identification of glucoside and carboxyl-linked glucuronide conjugates of mycophenolic acid in plasma of transplant recipients treated with mycophenolate mofetil

1. Mycophenolic acid (MPA), is primarily metabolized in the liver to 7-O-MPA-β-glucuronide (MPAG). Using RP-h.p.l.c. we observed three further MPA metabolites, M-1, M-2, M-3, in plasma of transplant recipients on MMF therapy. To obtain information on the structure and source of these metabolites: (A...

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Main Authors: Shipkova, Maria, Armstrong, Victor William, Wieland, Eberhard, Niedmann, Paul Dieter, Schütz, Ekkehard, Brenner-Weiß, Gerald, Voihsel, Martin, Braun, Felix, Oellerich, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565876/
https://ncbi.nlm.nih.gov/pubmed/10204993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702399
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