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Antagonist activity of α-substituted 4-carboxyphenylglycine analogues at group I metabotropic glutamate receptors expressed in CHO cells

1. We have investigated the antagonist properties of 6 α-substituted phenylglycine analogues based on the structure of 4-carboxyphenylglycine (4-CPG) for group I metabotropic glutamate receptors (mGlu(1α) and mGlu(5a)) permanently expressed in CHO cells. 2. (S)-4-CPG and (S)-MCPG were the most selec...

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Detalhes bibliográficos
Main Authors: Doherty, A J, Collingridge, G L, Jane, D E
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565801/
https://ncbi.nlm.nih.gov/pubmed/10051137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702297
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