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Desensitization of the histamine H(1)-receptor and transcriptional down-regulation of histamine H(1)-receptor gene expression in bovine tracheal smooth muscle
1. We have investigated the role of protein kinase C (PKC) in the desensitization of histamine H(1)-receptors and in the expression of the histamine H(1)-receptor gene in airway smooth muscle. 2. Prolonged 4β-phorbol 12,13 dibutyrate (PDBu) pretreatment (4 h, 100 nM–1 μM) of bovine trachealis caused...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1565733/ https://ncbi.nlm.nih.gov/pubmed/9884076 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702222 |
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