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Inhibition of the rapid component of the delayed-rectifier K(+) current by therapeutic concentrations of the antispasmodic agent terodiline

1. Prolongation of the QT interval and malignant ventricular arrhythmia have been observed in patients administered terodiline for urinary incontinence. Since this adverse reaction might be caused by inhibition of delayed-rectifier K(+) current (I(K)), we investigated whether clinically relevant (⩽1...

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Detalhes bibliográficos
Main Authors: Jones, Stephen E, Ogura, Toshitsugu, Shuba, Lesya M, McDonald, Terence F
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565686/
https://ncbi.nlm.nih.gov/pubmed/9863639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702173
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