Glycodermorphins: opioid peptides with potent and prolonged analgesic activity and enhanced blood-brain barrier penetration

1. In order to improve the in vivo stability of the opioid peptide dermorphin we synthesized O-βglucosylated analogs ([Ser(7)-O-βGlc]dermorphin and [Ser(7)-O-βGlc(Ac)(4)]-dermorphin) and C-αgalactosylated analogs ([Ala(7)-C-αGal]dermorphin and [Ala(7)-C-αGal(Ac)(4)]-dermorphin). 2. O- and C-glycosyl...

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Bibliographic Details
Main Authors: Negri, Lucia, Lattanzi, Roberta, Tabacco, Fabio, Scolaro, Barbara, Rocchi, Raniero
Format: Artigo
Language:Inglês
Published: 1998
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Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565530/
https://ncbi.nlm.nih.gov/pubmed/9723966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701971
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