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Nitric oxide-induced cytotoxicity attenuation by thiopentone sodium but not pentobarbitone sodium in primary brain cultures

1. We describe the effects of barbiturates on the neurotoxicity induced by nitric oxide (NO) on foetal rat cultured cortical and hippocampal neurones. Cessation of cerebral blood flow leads to an initiation of a neurotoxic cascade including NO and peroxynitrite. Barbiturates are often used to protec...

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Detalhes bibliográficos
Main Authors: Shibuta, Satoshi, Kosaka, Jun, Mashimo, Takashi, Fukuda, Yutaka, Yoshiya, Ikuto
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565441/
https://ncbi.nlm.nih.gov/pubmed/9690874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701884
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