Inhibition of nitric oxide generation unmasks vascular dysfunction in insulin-resistant, obese JCR:LA-cp rats

1. The effects of nitric oxide (NO) on vascular reactivity and platelet function in the obese (cp/cp) and lean (+/?) JCR:LA-cp rats were investigated. 2. Phenylephrine (PE; 0.1 nM–10 μM) induced contraction of isolated aortic rings in both genotypes (cp/cp and +/?) of JCR:LA-cp rats. The sensitivity...

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Detalhes bibliográficos
Main Authors: McKendrick, Joyce D, Salas, Eduardo, Dubé, Gregory P, Murat, Jesus, Russell, James C, Radomski, Marek W
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
Assuntos:
Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565384/
https://ncbi.nlm.nih.gov/pubmed/9641554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701829
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