Gabapentin potentiation of the antiepileptic efficacy of vigabatrin in an in vitro model of epilepsy

1. An enhancement of promoted release of γ-aminobutyric acid (GABA) and a change in GABA-metabolism have been suggested as mechanisms of action of gabapentin. Vigabatrin is supposed to act mainly via inhibition of GABA-transaminase but it also interferes with GABA-release and GABA-uptake. On the bas...

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Detaylı Bibliyografya
Asıl Yazarlar: Lücke, A, Mußhoff, U, Köhling, R, Osterfeld, M, Mayer, T, Wolf, P, Schütte, W, Speckmann, E-J
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1998
Konular:
Papers
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565383/
https://ncbi.nlm.nih.gov/pubmed/9641555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701825
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