Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT(1B) and 5-HT(1D) receptors expressed in various mammalian cell lines

1. Alniditan, a novel migraine abortive agent, is a potent 5-HT(1B)/5-HT(1D) receptor agonist of nM affinity. We compared the agonistic properties of alniditan, sumatriptan and dihydroergotamine on the cloned human 5-HT(1B) receptor expressed at 200 fmol mg(−1) protein (B(max)) in non-induced L929sA...

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Detalhes bibliográficos
Main Authors: Lesage, Anne S, Wouters, Ria, Van Gompel, Paul, Heylen, Lieve, Vanhoenacker, Peter, Haegeman, Guy, Luyten, Walter H M L, Leysen, Josée E
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565323/
https://ncbi.nlm.nih.gov/pubmed/9605573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701766
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