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Relaxant effects of NKH477, a new water-soluble forskolin derivative, on guinea-pig tracheal smooth muscle: the role of Ca(2+)-activated K(+) channels

1. Mechanisms underlying the bronchorelaxant action of NKH477, a newly developed water-soluble forskolin derivative, were investigated in guinea-pig isolated tracheal smooth muscle. 2. In muscles precontracted with 3 μM histamine, NKH477 (1 nM–1 μM) caused a concentration-dependent decrease of isome...

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Detalhes bibliográficos
Main Authors: Satake, K, Takagi, K, Kodama, I, Honjo, H, Toyama, J, Shibata, S
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565213/
https://ncbi.nlm.nih.gov/pubmed/9517396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701655
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