Lipopolysaccharide induces expression of tumour necrosis factor alpha in rat brain: inhibition by methylprednisolone and by rolipram

1. We have investigated the effects of the phosphodiesterase (PDE) type IV inhibitor rolipram and of the glucocorticoid methylprednisolone on the induction of tumour necrosis factor alpha (TNF-α) mRNA and protein in brains of rats after peripheral administration of lipopolysaccharide (LPS). 2. After...

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Detalhes bibliográficos
Main Authors: Buttini, M, Mir, A, Appel, K, Wiederhold, K H, Limonta, S, Gebicke-Haerter, P J, Boddeke, H W G M
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565066/
https://ncbi.nlm.nih.gov/pubmed/9421299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701502
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