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Effects of a novel guanylate cyclase inhibitor on nitric oxide-dependent inhibitory neurotransmission in canine proximal colon

1. Previous studies suggested that nitric oxide (NO) may cause hyperpolarization and relaxation of canine colonic smooth muscle by both cGMP-dependent and cGMP-independent mechanisms. This hypothesis was tested using 1H-[1,2,4]oxadiazolo[4,3-a]quinoxaline-1-one (ODQ), a novel inhibitor of NO-stimula...

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書誌詳細
主要な著者: Franck, H, Sweeney, K M, Sanders, K M, Shuttleworth, C W R
フォーマット: Artigo
言語:Inglês
出版事項: 1997
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565046/
https://ncbi.nlm.nih.gov/pubmed/9401790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701487
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