Differential regulation of cyclo-oxygenase-2 and 5-lipoxygenase-activating protein (FLAP) expression by glucocorticoids in monocytic cells

1. The objective of the present study was to determine the effects of dexamethasone on key constituents of prostaglandin and leukotriene biosynthesis, cyclo-oxygenase-2 (COX-2) and 5-lipoxygenase activating protein (FLAP). The human monocytic cell line THP-1 was used as a model system. mRNA and prot...

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Bibliographic Details
Main Authors: Goppelt-Struebe, M, Schaefer, D, Habenicht, A J R
Format: Artigo
Language:Inglês
Published: 1997
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Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1564983/
https://ncbi.nlm.nih.gov/pubmed/9375956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701425
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