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RPR 106541, a novel, airways-selective glucocorticoid: effects against antigen-induced CD4(+)T lymphocyte accumulation and cytokine gene expression in the Brown Norway rat lung
1. The effects of a novel 17-thiosteroid, RPR 106541, were investigated in a rat model of allergic airway inflammation. 2. In sensitized Brown Norway rats, challenge with inhaled antigen (ovalbumin) caused an influx of eosinophils and neutrophils into the lung tissue and airway lumen. In the lung ti...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
1997
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1564957/ https://ncbi.nlm.nih.gov/pubmed/9351499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701398 |
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