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The antiarrhythmic agent bertosamil induces inactivation of the sustained outward K(+) current in human atrial myocytes

1. In whole-cell patch-clamped human atrial myocytes, the antiarrhythmic agent bertosamil (10 μM) inhibited the sustained component, I(sus) (38.6±3.1%), and enhanced the inactivating component, I(t) (9.1±6.1%), of the outward K(+) current elicited by 750 ms test pulses from −60 mV to +50 mV. Higher...

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Detalhes bibliográficos
Main Authors: Tessier, Sophie, Rücker-Martin, Catherine, Macé, Loïc, Coraboeuf, Edouard, Mercadier, Jean-Jacques, Hatem, Stéphane N
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1564926/
https://ncbi.nlm.nih.gov/pubmed/9313938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701369
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