Profile of SB-204269, a mechanistically novel anticonvulsant drug, in rat models of focal and generalized epileptic seizures

1. Earlier optimization of structure-activity relationships in a novel series of 4-(benzoylamino)-benzopyrans, led to the discovery of SB-204269 (trans-(+)-6-acetyl-4S-(4-fluorobenzoylamino)-3,4-dihydro-2,2-dimethyl-2H-benzo[b]pyran-3R-ol, hemihydrate), a potent orally-active anticonvulsant in the m...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Upton, Neil, Blackburn, Tom P, Campbell, Colin A, Cooper, Duncan, Evans, Martyn L, Herdon, Hugh J, King, Penny D, Ray, Alison M, Stean, Tania O, Chan, Wai N, Evans, John M, Thompson, Mervyn
Format: Artigo
Langue:Inglês
Publié: 1997
Sujets:
Papers
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1564882/
https://ncbi.nlm.nih.gov/pubmed/9283703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701330
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