Effect of a novel selective and potent phosphinic peptide inhibitor of endopeptidase 3.4.24.16 on neurotensin-induced analgesia and neuronal inactivation

1. We have examined a series of novel phosphinic peptides as putative potent and selective inhibitors of endopeptidase 3.4.24.16. 2. The most selective inhibitor, Pro-Phe-Ψ(PO(2)CH(2))-Leu-Pro-NH(2) displayed a K(i) value of 12 nM towards endopeptidase 3.4.24.16 and was 5540 fold less potent on its...

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Detalhes bibliográficos
Main Authors: Vincent, Bruno, Jiracek, Jirì, Noble, Florence, Loog, Mart, Roques, Bernard, Dive, Vincent, Vincent, Jean-Pierre, Checler, Frédéric
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1564740/
https://ncbi.nlm.nih.gov/pubmed/9208137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701182
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