Ro 32-3555, an orally active collagenase inhibitor, prevents cartilage breakdown in vitro and in vivo

1. Ro 32-3555 (3(R)-(cyclopentylmethyl) - 2(R) - [(3,4,4 - trimethyl-2,5-dioxo-1-imidazolidinyl)methyl] - 4-oxo-4-piperidinobutyrohydroxamic acid) is a potent, competitive inhibitor of human collagenases 1, 2 and 3 (K(i) values of 3.0, 4.4 and 3.4 nM, respectively). The compound is a selective inhib...

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Detalhes bibliográficos
Main Authors: Lewis, E J, Bishop, J, Bottomley, K M K, Bradshaw, D, Brewster, M, Broadhurst, M J, Brown, P A, Budd, J M, Elliott, L, Greenham, A K, Johnson, W H, Nixon, J S, Rose, F, Sutton, B, Wilson, K
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1564706/
https://ncbi.nlm.nih.gov/pubmed/9179398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701150
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