The ability of a new hypoglycaemic agent, A-4166, compared to sulphonylureas, to increase cytosolic Ca(2+) in pancreatic β-cells under metabolic inhibition

1. N-(trans-4-isopropylcyclohexanecarbonyl)-D-phenylalanine (A-4166) is a new non-sulphonylurea oral hypoglycaemic agent which stimulates insulin release by increasing cytosolic Ca(2+) concentration ([Ca(2+)](i)) in β-cells. 2. We studied comparative effects of A-4166 and sulphonylureas on [Ca(2+)](...

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Detaylı Bibliyografya
Asıl Yazarlar: Fujitani, Shoji, Okazaki, Kyoko, Yada, Toshihiko
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1997
Konular:
Papers
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1564588/
https://ncbi.nlm.nih.gov/pubmed/9105692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701017
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