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Negative modulation of nitric oxide production by neurotensin as a putative mechanism of the diuretic action of SR 48692 in rats
1. We investigated the effect of the non-peptide neurotensin (NT) antagonist SR 48692 on renal function in rats and the involvement of nitric oxide (NO) in the diuretic action of this compound. 2. In fed animals, SR 48692 dose-dependently (0.5 to 12.5 mg kg(−1), p.o., 0.03 to 1 mg kg(−1), i.p. and 0...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
1997
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1564587/ https://ncbi.nlm.nih.gov/pubmed/9105707 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701016 |
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