Kaposi's Sarcoma-Associated Herpesvirus Latent Protein LANA Interacts with HIF-1α To Upregulate RTA Expression during Hypoxia: Latency Control under Low Oxygen Conditions

Hypoxia can induce lytic replication of Kaposi's sarcoma-associated herpesvirus (KSHV) in primary effusion lymphoma (PEL) cells. However, the molecular mechanism of lytic reactivation of KSHV by hypoxia remains unclear. Here we show that the latency-associated nuclear antigen (LANA), which play...

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Auteurs principaux: Cai, Qiliang, Lan, Ke, Verma, Subhash C., Si, Huaxin, Lin, Doug, Robertson, Erle S.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2006
Sujets:
Virus-Cell Interactions
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1563785/
https://ncbi.nlm.nih.gov/pubmed/16873253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00689-06
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