Cyclosporine Increases Human Immunodeficiency Virus Type 1 Vector Transduction of Primary Mouse Cells

Murine primary cells are poorly permissive to human immunodeficiency virus type 1 (HIV-1) vector infection. Retroviral infectivity is influenced by dominant inhibitors such as TRIM5α. Sensitivity to TRIM5α is altered by interactions between cyclophilin A and the HIV-1 capsid. Here we demonstrate tha...

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Bibliographic Details
Main Authors: Noser, Josh A., Towers, Greg J., Sakuma, Ryuta, Dumont, Jean-Maurice, Collins, Mary K. L., Ikeda, Yasuhiro
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1563702/
https://ncbi.nlm.nih.gov/pubmed/16840358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02427-05
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