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Targeting of the Human Immunodeficiency Virus Type 1 Envelope to the trans-Golgi Network through Binding to TIP47 Is Required for Env Incorporation into Virions and Infectivity

Here, we report that human immunodeficiency virus type 1 (HIV-1) Env glycoprotein is located mainly in the trans-Golgi network (TGN) due to determinants present in the cytoplasmic domain of the transmembrane gp41 glycoprotein (TMgp41). Internalization assays demonstrated that Env present at the cell...

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Autori principali: Blot, Guillaume, Janvier, Katy, Le Panse, Sophie, Benarous, Richard, Berlioz-Torrent, Clarisse
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC156179/
https://ncbi.nlm.nih.gov/pubmed/12768012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.12.6931-6945.2003
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