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Mitogen-activated protein kinases interacting kinases are autoinhibited by a reprogrammed activation segment
Autoinhibition is a recurring mode of protein kinase regulation and can be based on diverse molecular mechanisms. Here, we show by crystal structure analysis, nuclear magnetic resonance (NMR)-based nucleotide affinity studies and rational mutagenesis that nonphosphorylated mitogen-activated protein...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2006
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1560367/ https://ncbi.nlm.nih.gov/pubmed/16917500 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601285 |
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