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Structural basis of lipid biosynthesis regulation in Gram-positive bacteria

Malonyl-CoA is an essential intermediate in fatty acid synthesis in all living cells. Here we demonstrate a new role for this molecule as a global regulator of lipid homeostasis in Gram-positive bacteria. Using in vitro transcription and binding studies, we demonstrate that malonyl-CoA is a direct a...

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Detalhes bibliográficos
Main Authors: Schujman, Gustavo E, Guerin, Marcelo, Buschiazzo, Alejandro, Schaeffer, Francis, Llarrull, Leticia I, Reh, Georgina, Vila, Alejandro J, Alzari, Pedro M, de Mendoza, Diego
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1560364/
https://ncbi.nlm.nih.gov/pubmed/16932747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601284
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