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Experimental Study of LY333328 (Oritavancin), Alone and in Combination, in Therapy of Cephalosporin-Resistant Pneumococcal Meningitis

Using a rabbit model of meningitis, we sought to determine the efficacy of LY333328, a semisynthetic glycopeptide, in the treatment of cephalosporin-resistant pneumococcal meningitis. LY333328 was administered at a dose of 10 mg/kg of body weight/day, alone and in combination with ceftriaxone at 100...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Cabellos, Carmen, Fernàndez, Antonio, Maiques, Jose M., Tubau, Fe, Ardanuy, Carmen, Viladrich, Pedro F., Liñares, Josefina, Gudiol, Francesc
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2003
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC155831/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12760866/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.6.1907-1911.2003
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