ICP0 antagonizes Stat 1-dependent repression of herpes simplex virus: implications for the regulation of viral latency

BACKGROUND: The herpes simplex virus type 1 (HSV-1) ICP0 protein is an E3 ubiquitin ligase, which is encoded within the HSV-1 latency-associated locus. When ICP0 is not synthesized, the HSV-1 genome is acutely susceptible to cellular repression. Reciprocally, when ICP0 is synthesized, viral replicat...

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Autors principals: Halford, William P, Weisend, Carla, Grace, Jennifer, Soboleski, Mark, Carr, Daniel JJ, Balliet, John W, Imai, Yumi, Margolis, Todd P, Gebhardt, Bryan M
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2006
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1557838/
https://ncbi.nlm.nih.gov/pubmed/16764725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-3-44
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