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The μ-opioid receptor gene and smoking initiation and nicotine dependence

The gene encoding the mu-opioid receptor (OPRM1) is reported to be associated with a range of substance dependence. Experiments in knockout mice indicate that the mu-opioid receptor may mediate reinforcing effects of nicotine. In humans, opioid antagonist naltrexone may reduce the reinforcing effect...

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Bibliographic Details
Main Authors: Zhang, Lan, Kendler, Kenneth S, Chen, Xiangning
Format: Artigo
Language:Inglês
Published: BioMed Central 2006
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1557520/
https://ncbi.nlm.nih.gov/pubmed/16887046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-9081-2-28
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