Testosterone reduces neuronal secretion of Alzheimer's β-amyloid peptides

Alzheimer's disease (AD) is characterized by the age-related deposition of β-amyloid (Aβ) 40/42 peptide aggregates in vulnerable brain regions. Multiple levels of evidence implicate a central role for Aβ in the pathophysiology of AD. Aβ peptides are generated by the regulated cleavage of an ≈700-aa...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Gouras, Gunnar K., Xu, Huaxi, Gross, Rachel S., Greenfield, Jeffrey P., Hai, Bing, Wang, Rong, Greengard, Paul
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2000
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15568/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10655508/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.3.1202
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