Human CD4(+) CD25(hi) Foxp3(+) regulatory T cells are derived by rapid turnover of memory populations in vivo

While memory T cells are maintained by continuous turnover, it is not clear how human regulatory CD4(+)CD45RO(+)CD25(hi) Foxp3(+) T lymphocyte populations persist throughout life. We therefore used deuterium labeling of cycling cells in vivo to determine whether these cells could be replenished by p...

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Autori principali: Vukmanovic-Stejic, Milica, Zhang, Yan, Cook, Joanne E., Fletcher, Jean M., McQuaid, Arthur, Masters, Joanne E., Rustin, Malcolm H.A., Taams, Leonie S., Beverley, Peter C.L., Macallan, Derek C., Akbar, Arne N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2006
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1555646/
https://ncbi.nlm.nih.gov/pubmed/16955142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI28941
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