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The effect of microsomal enzyme inhibition on the immunosuppressive and toxic effects of cyclophosphamide
Cyclophosphamide is activated in vivo to toxic alkylating materials by hepatic microsomal enzymes. In mice and rats, inhibition of these enzymes by chloramphenicol or SKF 525A reduces the toxicity of cyclophosphamide but has less effect in rats and no effect in mice on its immunosuppressive activity...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
1973
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1553799/ https://ncbi.nlm.nih.gov/pubmed/4717916 |
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