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fzr-1 and lin-35/Rb function redundantly to control cell proliferation in C. elegans as revealed by a nonbiased synthetic screen

We report here a synthetic-lethal screen in Caenorhabditis elegans that overcomes a number of obstacles associated with the analysis of functionally redundant genes. Using this approach, we have identified mutations that synthetically interact with lin-35/Rb, a SynMuv gene and the sole member of the...

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Detalhes bibliográficos
Main Authors: Fay, David S., Keenan, Sean, Han, Min
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC155341/
https://ncbi.nlm.nih.gov/pubmed/11850412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.952302
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