Interleukin-13 Induction of 15-Lipoxygenase Gene Expression Requires p38 Mitogen-Activated Protein Kinase-Mediated Serine 727 Phosphorylation of Stat1 and Stat3

Interleukin-13 (IL-13) is a cytokine secreted by Th2 lymphocytes that is capable of inducing expression of 15-lipoxygenase (15-LO) in primary human monocytes. We recently demonstrated that induction of 15-LO requires the activation of Jak2 and Tyk2 kinases and Stats 1, 3, 5, and 6. Since IL-13-induc...

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Main Authors: Xu, Bo, Bhattacharjee, Ashish, Roy, Biswajit, Xu, Hong-Min, Anthony, David, Frank, David A., Feldman, Gerald M., Cathcart, Martha K.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2003
Assuntos:
Cell Growth and Development
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC155212/
https://ncbi.nlm.nih.gov/pubmed/12748293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.11.3918-3928.2003
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