Cooperation of the Inducible Nitric Oxide Synthase and Cytochrome P450 1A1 in Mediating Lung Inflammation and Mutagenicity Induced by Diesel Exhaust Particles

Diesel exhaust particles (DEPs) have been shown to activate oxidant generation by alveolar macrophages (AMs), alter xenobiotic metabolic pathways, and modify the balance of pro-antiinflammatory cytokines. In this study we investigated the role of nitric oxide (NO) in DEP-mediated and DEP organic ext...

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Detalhes bibliográficos
Main Authors: Zhao, Hongwen, Barger, Mark W., Ma, Joseph K.H., Castranova, Vincent, Ma, Jane Y.C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Institute of Environmental Health Sciences 2006
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1552032/
https://ncbi.nlm.nih.gov/pubmed/16882535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.9063
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