Application of Cryopreserved Human Hepatocytes in Trichloroethylene Risk Assessment: Relative Disposition of Chloral Hydrate to Trichloroacetate and Trichloroethanol

BACKGROUND: Trichloroethylene (TCE) is a suspected human carcinogen and a common ground-water contaminant. Chloral hydrate (CH) is the major metabolite of TCE formed in the liver by cytochrome P450 2E1. CH is metabolized to the hepatocarcinogen trichloroacetate (TCA) by aldehyde dehydrogenase (ALDH)...

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Main Authors: Bronley-DeLancey, Apryl, McMillan, David C., McMillan, JoEllyn M., Jollow, David J., Mohr, Lawrence C., Hoel, David G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Institute of Environmental Health Sciences 2006
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1551986/
https://ncbi.nlm.nih.gov/pubmed/16882532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.9047
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