Effects of Inactivation and Constitutive Expression of the Unfolded- Protein Response Pathway on Protein Production in the Yeast Saccharomyces cerevisiae

One strategy to obtain better yields of secreted proteins has been overexpression of single endoplasmic reticulum-resident foldases or chaperones. We report here that manipulation of the unfolded-protein response (UPR) pathway regulator, HAC1, affects production of both native and foreign proteins i...

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Pubblicato in:	Appl Environ Microbiol
Autori principali:	Valkonen, Mari, Penttilä, Merja, Saloheimo, Markku
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2003
Soggetti:	Physiology and Biotechnology
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC154816/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12676684/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AEM.69.4.2065-2072.2003
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