Engineering Streptomyces clavuligerus Deacetoxycephalosporin C Synthase for Optimal Ring Expansion Activity toward Penicillin G

The deacetoxycephalosporin C synthase (DAOCS) from Streptomyces clavuligerus was engineered with the aim of enhancing the conversion of penicillin G into phenylacetyl-7-aminodeacetoxycephalosporanic acid, a precursor of 7-aminodeacetoxycephalosporanic acid, for industrial application. A single round...

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Detalhes bibliográficos

Publicado no:	Appl Environ Microbiol
Principais autores:	Wei, Chia-Li, Yang, Yunn-Bor, Wang, Wen-Ching, Liu, Wen-Chi, Hsu, Jyh-Shing, Tsai, Ying-Chieh
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2003
Assuntos:	Enzymology and Protein Engineering
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC154807/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12676714/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AEM.69.4.2306-2312.2003
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