Improvement of Differentiation and Interpretability of Spoligotyping for Mycobacterium tuberculosis Complex Isolates by Introduction of New Spacer Oligonucleotides

The direct repeat (DR) region in Mycobacterium tuberculosis complex strains is composed of multiple well-conserved 36-bp DRs interspersed with nonrepetitive DNA spacer sequences of similar size. Clinical isolates show extensive polymorphism in this DR region, and this has led to the development of a...

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Autores principales: van der Zanden, A. G. M., Kremer, K., Schouls, L. M., Caimi, K., Cataldi, A., Hulleman, A., Nagelkerke, N. J. D., van Soolingen, D.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2002
Materias:
Mycobacteriology and Aerobic Actinomycetes
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC154657/
https://ncbi.nlm.nih.gov/pubmed/12454164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.40.12.4628-4639.2002
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