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Pharmacokinetic observations of phenytoin disposition in the newborn and young infant.

The pharmacokinetic profile of phenytoin (DPH) was studied in 30 infants aged 2 days to 96 weeks. The plasma DPH half-life during the first week of life in term infants was prolonged and very variable (20-7 +/- 11-6 h, mean +/-SD). Thereafter the plasma half-life was much shorter (7-6 +/- 3-5 h). In...

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Hlavní autoři: Loughnan, P M, Greenwald, A, Purton, W W, Aranda, J V, Watters, G, Neims, A H
Médium: Artigo
Jazyk:Inglês
Vydáno: 1977
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1544674/
https://ncbi.nlm.nih.gov/pubmed/871217
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