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Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

Functions of receptor tyrosine kinases implicated in angiogenesis were pharmacologically impaired in a mouse model of pancreatic islet cancer. An inhibitor targeting VEGFRs in endothelial cells (SU5416) is effective against early-stage angiogenic lesions, but not large, well-vascularized tumors. In...

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Detalhes bibliográficos
Main Authors: Bergers, Gabriele, Song, Steven, Meyer-Morse, Nicole, Bergsland, Emily, Hanahan, Douglas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC154450/
https://ncbi.nlm.nih.gov/pubmed/12727920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200317929
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