Induction of immune tolerance to coagulation factor IX antigen by in vivo hepatic gene transfer

Gene replacement therapy is an attractive approach for treatment of genetic disease, but may be complicated by the risk of a neutralizing immune response to the therapeutic gene product. There are examples of humoral and cellular immune responses against the transgene product as well as absence of s...

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Main Authors: Mingozzi, Federico, Liu, Yi-Lin, Dobrzynski, Eric, Kaufhold, Antje, Liu, Jian Hua, Wang, YuQin, Arruda, Valder R., High, Katherine A., Herzog, Roland W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2003
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC154443/
https://ncbi.nlm.nih.gov/pubmed/12727926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200316887
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