Cell cycle regulator E2F1 modulates angiogenesis via p53-dependent transcriptional control of VEGF

The transcription factor E2F1 is known to regulate cell proliferation and has been thought to modulate tumorigenesis via this mechanism alone. Here we show that mice deficient in E2F1 exhibit enhanced angiogenesis. The proangiogenic phenotype in E2F1 deficiency is the result of overproduction of vas...

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Bibliografiska uppgifter
Huvudupphovsmän: Qin, Gangjian, Kishore, Raj, Dolan, Christine M., Silver, Marcy, Wecker, Andrea, Luedemann, Corinne N., Thorne, Tina, Hanley, Allison, Curry, Cynthia, Heyd, Lindsay, Dinesh, Deepika, Kearney, Marianne, Martelli, Fabio, Murayama, Toshinori, Goukassian, David A., Zhu, Yan, Losordo, Douglas W.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2006
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1544166/
https://ncbi.nlm.nih.gov/pubmed/16835303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509533103
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