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Altered positive selection due to corecognition of floppy peptide/MHC II conformers supports an integrative model of thymic selection
Thymocytes bearing the Eα52-68/I-A(b) complex-specific 1H3.1 αβ T cell antigen receptor are positively selected in Ab-Ep [Ab-Ep transgenic, invariant chain (Ii)(−/−), I-Aβ(b−/−)] mice, where I-A(b) molecules present only Eα52-68. Although Ii reintroduction led to deletion, I-Aβ(b) reintroduction dis...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
The National Academy of Sciences
2003
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC154349/ https://ncbi.nlm.nih.gov/pubmed/12700352 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0831129100 |
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