Modeling del(17)(p11.2p11.2) and dup(17)(p11.2p11.2) Contiguous Gene Syndromes by Chromosome Engineering in Mice: Phenotypic Consequences of Gene Dosage Imbalance

Contiguous gene syndromes (CGS) are a group of disorders associated with chromosomal rearrangements of which the phenotype is thought to result from altered copy numbers of physically linked dosage-sensitive genes. Smith-Magenis syndrome (SMS) is a CGS associated with a deletion within band p11.2 of...

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Detalhes bibliográficos
Main Authors: Walz, Katherina, Caratini-Rivera, Sandra, Bi, Weimin, Fonseca, Patricia, Mansouri, Dena L., Lynch, Jennifer, Vogel, Hannes, Noebels, Jeffrey L., Bradley, Allan, Lupski, James R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC154242/
https://ncbi.nlm.nih.gov/pubmed/12724422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.10.3646-3655.2003
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